He was diagnosed with the disease in March of 2008. Despite having cancer, he continued working, finishing 13 episodes of the TV drama The Beast. He refused to take painkillers as this, he said, would have taken the edge off his performances.
His publicist Annett Wolf said Patrick died peacefully with his family by his side in Los Angeles.
Patrick started his career in Hollywood in the roller-skate disco movie Skatetown USA (1979) and best known for his roles as the sexy rebel Johnny Castle in Dirty Dancing (1987) and loving partner Sam Wheat to Demi Moore's Molly Jensen in the worldwide blockbuster Ghost (1990).